Learning Resources

Comprehensive collection of scientific literature, coding exercises, and interactive tools for protein design education

Scientific Literature

Curated papers from leading journals in structural biology and computational science

Breakthrough Paper2021
AlphaFold: a solution to a 50-year-old grand challenge in biology

Jumper et al.Nature

The landmark paper describing AlphaFold's protein structure prediction capabilities.

Review2003
Protein folding and misfolding

Dobson, C.M.Nature

Comprehensive review of protein folding mechanisms and diseases.

AI/ML2022
De novo protein design by deep network hallucination

Anand & HuangNature

Novel approach to protein design using generative neural networks.

Foundation2012
Principles of protein folding

Dill & MacCallumScience

Fundamental principles governing how proteins fold into their native structures.

Coding Exercises

Hands-on Python programming with BioPython, PyMOL, and molecular simulation tools

BeginnerWeek 1-2
Protein Sequence Analysis

Language: Python

Basic sequence manipulation, FASTA parsing, and amino acid properties

Included Files:

sequence_analysis.pyamino_acid_props.py
IntermediateWeek 3-4
Structure Visualization with PyMOL

Language: Python

Automated structure visualization and analysis using PyMOL API

Included Files:

pymol_scripts.pystructure_analysis.py
AdvancedWeek 7-8
Molecular Dynamics Setup

Language: Python

Setting up and running MD simulations with GROMACS and MDAnalysis

Included Files:

md_setup.pytrajectory_analysis.py
IntermediateWeek 10
AlphaFold Integration

Language: Python

Accessing and analyzing AlphaFold predictions programmatically

Included Files:

alphafold_api.pyconfidence_analysis.py

Interactive Tools

Web-based applications for exploring protein structures, dynamics, and design principles

Web ApplicationExternal
Mol* Molecular Viewer

Advanced 3D molecular visualization in the browser

Key Features:

  • PDB structure loading
  • Custom styling
  • Animation support
Open Tool
DatabaseExternal
Protein Data Bank Browser

Searchable database of protein structures with integrated tools

Key Features:

  • Structure search
  • Sequence alignment
  • Download options
Open Tool
Interactive Plot
Energy Landscape Explorer

Visualize protein folding energy landscapes and pathways

Key Features:

  • 3D energy plots
  • Folding pathways
  • Temperature effects
Launch Tool
Simulation Tool
Folding Animation Studio

Create and view protein folding animations

Key Features:

  • Step-by-step folding
  • Custom proteins
  • Export animations
Launch Tool

Additional Resources

Textbooks & References

Essential textbooks and reference materials for deeper understanding

View Reading List
Exercises & Tools

Coding exercises and installation guides for bioinformatics software

Databases & Repositories

Links to major protein databases and structural repositories

Database Links