Essential protein databases and repositories for structural biology and computational protein design
The worldwide repository for 3D structural data of biological macromolecules
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Comprehensive resource for protein sequence and annotation data
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AI-predicted protein structures covering the human proteome and key organisms
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Structural Classification of Proteins database for evolutionary relationships
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Comprehensive enzyme information system
Focus: Enzyme kinetics, structure, function
Access DatabaseKyoto Encyclopedia of Genes and Genomes
Focus: Metabolic pathways, enzyme reactions
Access DatabaseSIB Bioinformatics Resource Portal
Focus: Proteomics tools and databases
Access DatabaseOrientations of Proteins in Membranes
Focus: Membrane protein structures and orientations
Access DatabaseMembrane Protein Structures
Focus: Curated membrane protein structures
Access DatabaseProtein families database based on multiple sequence alignments
Focus: Protein domain families and HMMs
Access DatabaseIntegrated resource of protein families, domains and sites
Focus: Protein classification and functional analysis
Access DatabaseClass, Architecture, Topology, Homology protein structure classification
Focus: Hierarchical protein structure classification
Access DatabaseMolecular Dynamics Extended Library
Focus: MD simulation data and analysis
Access DatabaseProtein backbone dynamics prediction
Focus: Backbone flexibility prediction
Access DatabaseGet structure metadata for PDB entry 1ABC
Get FASTA sequence for UniProt entry P04637
Get AlphaFold prediction for UniProt ID P04637
Most databases offer advanced search options with filters for resolution, method, organism, etc.
Use UniProt IDs to find corresponding PDB structures and AlphaFold predictions
Always verify resolution, R-factors, and confidence scores before using structures
For large datasets, use FTP sites or APIs rather than individual downloads