Thermodynamics & Energy Landscapes

This week covers: energy funnels, misfolding & aggregation, levinthal's paradox

Week Progress

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Core Concepts
  • Energy funnels
  • Misfolding & aggregation
  • Levinthal's paradox

Week Content

Section
30-45 min

Energy Landscapes

Understanding protein folding thermodynamics

Required Readings

The Protein-Folding Problem, 50 Years On

Required
Read

Protein folding landscape review

Required
Read
Exercises

Coding Exercise

Simulate toy energy landscape (2D potential surface)

Python
Start

Visualization

Plot funnel energy diagram in Matplotlib

Interactive
View