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Week 7Computation

Protein Modeling Basics

This week covers: homology modeling, threading and ab initio methods, pdb, uniprot, swissmodel resources

Week Progress

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Core Concepts
  • Homology modeling
  • Threading and ab initio methods
  • PDB, UniProt, SwissModel resources

Week Content

Section
30-45 min

Homology Modeling

Building protein models from known structures

Required Readings

SwissModel Tutorial

Required
Read

Intro to Comparative Modeling

Required
Read
Exercises

Coding Exercise

Query UniProt API to fetch protein sequences

Python
Start

Visualization

Compare modeled vs natural structure with Mol*

Interactive
View