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Week 4Section 1

Molecular Forces

Understanding the physical forces that stabilize proteins

30-45 minSection0/1 Activities Complete
Overview

Understanding the physical forces that stabilize proteins

Activities & Tasks
1

Hydrophobicity Analysis

Calculate and plot hydrophobicity profiles

coding
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Week Resources

Required Readings

Dominant forces in protein folding (Dill, 1990)
Read
Khan Academy Thermodynamics primer
Read

Exercises

Coding Exercise

Compute Kyte–Doolittle hydrophobicity index for a sequence

Visualization

Color-map hydrophobic vs hydrophilic residues in PyMOL

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