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Week 11Applications

Enzyme Design & Catalysis

This week covers: transition state stabilization, directed evolution, active site geometry

Week Progress

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Core Concepts
  • Transition state stabilization
  • Directed evolution
  • Active site geometry

Week Content

Section
30-45 min

Catalytic Mechanisms

Understanding enzyme function and design principles

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Required Readings

Frances Arnold Nobel Lecture (2018)

Required
Read

Enzyme Design Review

Required
Read
Exercises

Coding Exercise

Locate catalytic residues using PyRosetta API

Python
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Visualization

Highlight active site residues in PyMOL

Interactive
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